MULTITARGETING RNA IMMUNOTHERAPY COMPOSITIONS

A multi-targeting siRNA-aptamer platform is provided that is processed by cellular RNAi machinery to produce siRNAs. The constructs according to the invention are targeted at cells of the immune system. Methods of using the multi-targeting siRNA-aptamer for selectively targeting cells to down-regula...

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Bibliographic Details
Main Authors PENNER, Gregory Allen, MOUSSES, Spyro, FELDHEIM, Daniel, AZORSA, David, HEIL, James, TRAN, Necky
Format Patent
LanguageEnglish
French
Published 22.12.2022
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:A multi-targeting siRNA-aptamer platform is provided that is processed by cellular RNAi machinery to produce siRNAs. The constructs according to the invention are targeted at cells of the immune system. Methods of using the multi-targeting siRNA-aptamer for selectively targeting cells to down-regulate the expression of multiple genes are also provided. L'invention concerne des compositions d'ARNsi pour inhiber l'expression génique dans des cellules ciblées.
Bibliography:Application Number: WO2022US27902