MESSENGER RNA THERAPEUTICS AND COMPOSITIONS

• Main Authors: AULISA, Lorenzo, HILL, Ian, GREGG, Christopher, ABSHIRE, James Robbins, HUDSON, Michael, DE, Nabanita, SAMSA, Marcelo, FARMER, William, JAIN, Rachit, DAVITT, Christopher J.H, DHAMANKAR, Himanshu
• Format: Patent
• Language: English; French
• Published: 03.11.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

In the various aspects and embodiments, this disclosure provides messenger RNA (mRNA) constructs for therapeutic delivery, as well as methods for making such mRNA constructs and pharmaceutical compositions comprising the same (including mRNA vaccine compositions). In still other aspects, the invention provides methods for treating patients by expression of therapeutic proteins, including for preventing or reducing probability of infection by, or illness involving, a virus. Exemplary viruses include coronaviruses (such as SARS-CoV-2 and variants therefore) and influenza viruses, among others. Dans les divers aspects et modes de réalisation, cette divulgation concerne des constructions d'ARN messager (ARNm) pour une administration thérapeutique, ainsi que des procédés de fabrication de telles constructions d'ARNm et des compositions pharmaceutiques les comprenant (y compris des compositions de vaccin à ARNm). Dans d'autres aspects encore, l'invention concerne des procédés pour traiter des patients par l'expression de protéines thérapeutiques, y compris pour la prévention ou la réduction de la probabilité d'infection par, ou d'une maladie impliquant, un virus. Des exemples de virus comprennent des coronavirus (tels que le SARS-CoV-2 et des variants de ceux-ci) et des virus de la grippe, entre autres.