ASCORBIC ACID POLYPEPTIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF

• Main Authors: LI, Junxiang, KANG, Sining, LU, Yi, XU, Ming
• Format: Patent
• Language: Chinese; English; French
• Published: 03.11.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS

Provided in the present disclosure are an ascorbic acid polypeptide derivative, a preparation method therefor, and an application thereof, relating to the technical field of cosmetic raw material development, and the ascorbic acid polypeptide derivative being the compound represented by general formula (1) or a salt thereof. The ascorbic acid polypeptide derivative of a novel structure of the present disclosure has excellent VC whitening and carnosine anti-ageing effects, and solves the stability problem of traditional VC structures. Cell experiments demonstrate that the compound has good biological activity, including reducing ROS, promoting the production of collagen I, reducing tyrosinase activity, and down-regulating melanin secretion. At a concentration of 24.25 μm, the EAC-L-carnosine can down-regulate melanin secretion by 27.85%, greater than the sum of EAC and carnosine at the same concentration. The present invention is a promising anti-ageing active material with ideal anti-ageing effects in terms o