METHOD FOR PREPARING SPHINGOSINE-1-PHOSPHATE RECEPTOR AGONIST- CONTAINING ORAL SOLID PREPARATION BY WET GRANULATION

• Main Authors: KIM, Sook Hee, AHN, Jae Soon, YOO, Seok Cheol
• Format: Patent
• Language: English; French; Korean
• Published: 20.10.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention relates to a method for preparing a sphingosine-1-phosphate receptor agonist-containing oral solid preparation by wet granulation, and more specifically, to a method for preparing an oral solid preparation, wherein the oral solid preparation is prepared by wet granulation by using 1-[1-Chloro-6-(3-chloro-1-isopropyl-1H-indazol-5-ylmethoxy)-3,4-dihydro-naphthalen-2-ylmethyl]-piperidine-4-carboxylic acid of chemical formula 1, or a pharmaceutically acceptable salt thereof, together with sodium lauryl sulfate, as a solubilizing agent. La présente invention concerne un procédé de préparation d'une préparation solide orale contenant un agoniste du récepteur de la sphingosine-1-phosphate par granulation par voie humide, et plus précisément, un procédé de préparation d'une préparation solide orale, la préparation solide orale étant préparée par granulation par voie humide à l'aide d'acide 1-[1-chloro-6-(3-chloro-1-isopropyl-1H-indazol-5-ylméthoxy)-3,4-dihydro-naphtalén-2-ylméthyl]-pipéridine-4-carboxylique de formule chimique 1, ou d'un sel pharmaceutiquement acceptable associé, avec du laurylsulfate de sodium, en guise d'agent de solubilisation. 본 발명은 습식과립법에 의한 스핑고신-1-인산 수용체 효능제를 포함하는 경구형 고형 제제의 제조 방법에 관한 것으로, 보다 상세하게는 유효성분으로 화학식 1의 1-[1-클로로-6-(3-클로로-1-아이소프로필-1H-인다졸-5-일메톡시)-3,4-디하이드로-나프탈렌-2-일메틸]-피페리딘-4-카르복실산 또는 이의 약제학적으로 허용되는 염을, 가용화제로 라우릴황산나트륨과 함께 사용하여 습식과립법으로 제조하는 경구용 고형 제제의 제조 방법에 관한 것이다.