CD8-SPECIFIC ANTIBODY CONSTRUCTS AND COMPOSITIONS THEREOF

Disclosed herein are antibodies or antigen binding fragments thereof that specifically bind human CD8. Also disclosed are fusion proteins comprising a Henipavirus glycoprotein G and CD8 antibodies for targeting and transducing cells expressing CD8. Viral vectors and other compositions containing the...

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Bibliographic Details
Main Authors AMATYA, Shirisha, MACKENZIE, Lauren, HARDING, Hugh, CRUITE, Patricia
Format Patent
LanguageEnglish
French
Published 13.10.2022
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:Disclosed herein are antibodies or antigen binding fragments thereof that specifically bind human CD8. Also disclosed are fusion proteins comprising a Henipavirus glycoprotein G and CD8 antibodies for targeting and transducing cells expressing CD8. Viral vectors and other compositions containing the fusion proteins, as well as methods of using the fusion proteins, are also disclosed. La divulgation concerne des anticorps ou des fragments de liaison à l'antigène de ceux-ci qui se lient spécifiquement à CD8. La divulgation concerne également des protéines de fusion comprenant une glycoprotéine G et des anticorps CD8 de henipavirus pour cibler et transduire des cellules exprimant CD8. La divulgation concerne en outre des vecteurs viraux et d'autres compositions contenant les protéines de fusion, ainsi que des méthodes d'utilisation des protéines de fusion.
Bibliography:Application Number: WO2022US23807