ANTI-CORONAVIRUS CO-ADMINISTRATION THERAPEUTIC COMPOSITION COMPRISING CORONAVIRUS CELL ENTRY INHIBITOR AND CORONAVIRUS PROTEASE ACTIVITY INHIBITOR

• Main Authors: OH, Jong- Won, JUNG, Hae Gwang, SEO, Han Young
• Format: Patent
• Language: English; French; Korean
• Published: 13.10.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

One aspect relates to an anti-coronavirus composition comprising a coronavirus cell entry inhibitor and a coronavirus protease activity inhibitor or a pharmaceutical composition for preventing or treating a coronavirus infection. According to one aspect, when a coronavirus cell entry inhibitor and a coronavirus protease activity inhibitor are administered in combination, entry of the coronavirus into cells is inhibited, and even protease activity of the coronavirus is inhibited, thereby exhibiting a more remarkable synergistic effect in the anti-coronavirus effect and the prevention, improvement, or treatment effect of a coronavirus infection. Un aspect de la présente invention concerne une composition anticoronavirus comprenant un inhibiteur d'entrée de coronavirus dans les cellules et un inhibiteur d'activité de protéase de coronavirus ou une composition pharmaceutique pour la prévention ou le traitement d'une infection à coronavirus. Selon un aspect, lorsqu'un inhibiteur d'entrée de coronavirus dans les cellules et un inhibiteur d'activité de protéase de coronavirus sont administrés en association, l'entrée du coronavirus dans les cellules est inhibée, et même l'activité protéase du coronavirus est inhibée, de façon à présenter un effet synergique plus remarquable dans l'effet anticoronavirus et la prévention, l'amélioration ou l'effet du traitement d'une infection à coronavirus. 일 양상은 코로나바이러스의 세포 진입 억제제 및 코로나바이러스의 단백질분해효소 활성 억제제를 포함하는 항-코로나바이러스용 조성물 또는 코로나바이러스 감염증의 예방 또는 치료용 약학적 조성물에 관한 것이다. 일 양상에 따르면, 코로나바이러스의 세포 진입 억제제 및 코로나바이러스의 단백질분해효소 활성 억제제를 병용 투여하는 경우, 코로나바이러스의 세포 내 진입을 억제하고, 코로나바이러스의 단백질분해효소의 활성까지 억제함으로써, 항-코로나바이러스 효과 및 코로나바이러스 감염증의 예방, 개선 또는 치료 효과에 있어서 보다 현저한 시너지 효과를 나타낼 수 있다.