USES OF ANTI-TGFβ ANTIBODIES AND OTHER THERAPEUTIC AGENTS FOR THE TREATMENT OF PROLIFERATIVE DISEASES

Therapies using TGFβ inhibitors, PD-1 inhibitors, and/or chemotherapeutic agents are disclosed. These drugs at certain doses (including flat dosing) and regimens can be used to treat or prevent proliferative diseases such as solid tumors, including pancreatic or colorectal cancers. Further combinati...

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Bibliographic Details
Main Authors KHANSHAN, Fariba, DOSTALEK, Mirek, FABRE, Claire, SQUIRES, Matthew Simon, SHILKRUT, Mark
Format Patent
LanguageEnglish
French
Published 13.10.2022
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Therapies using TGFβ inhibitors, PD-1 inhibitors, and/or chemotherapeutic agents are disclosed. These drugs at certain doses (including flat dosing) and regimens can be used to treat or prevent proliferative diseases such as solid tumors, including pancreatic or colorectal cancers. Further combination and uses thereof are also disclosed. L'invention concerne des thérapies utilisant des inhibiteurs de TGFβ, des inhibiteurs de PD-1 et/ou des agents chimiothérapeutiques. Ces médicaments à certaines doses (y compris en dosage fixe) et régimes peuvent être utilisés pour traiter ou prévenir des maladies prolifératives telles que des tumeurs solides, y compris le cancer du pancréas ou le cancer colorectal. L'invention concerne également une autre combinaison et ses utilisations.
Bibliography:Application Number: WO2022IB53243