CARBOXY SUBSTITUTED GLUCOCORTICOID RECEPTOR AGONISTS

The present invention provides a compound of Formula I: (I) wherein R1 is H, halogen, C1-C3 alkyl, or C1-C3 alkoxy; R2 is H or halogen; and X is O, OCH2, or CH2, or a pharmaceutically acceptable salt thereof, wherein the compound of Formula I, or pharmaceutically acceptable salt thereof is useful fo...

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Bibliographic Details
Main Authors STITES, Ryan Edward, WURST, Jacqueline Mary
Format Patent
LanguageEnglish
French
Published 29.09.2022
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
STEROIDS
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Summary:The present invention provides a compound of Formula I: (I) wherein R1 is H, halogen, C1-C3 alkyl, or C1-C3 alkoxy; R2 is H or halogen; and X is O, OCH2, or CH2, or a pharmaceutically acceptable salt thereof, wherein the compound of Formula I, or pharmaceutically acceptable salt thereof is useful for treating autoimmune and inflammatory diseases, such as atopic dermatitis, rheumatoid arthritis, and lupus nephritis. La présente invention concerne un composé de Formule I : (I) dans laquelle R1 représente H, halogène, alkyle en C1-C3, ou alcoxy en C1-C3 ; R2 représente H ou halogène ; et X représente O, OCH2, ou CH2, ou un sel pharmaceutiquement acceptable de celui-ci, le composé de formule I ou un sel pharmaceutiquement acceptable de celui-ci étant utile pour le traitement de maladies auto-immunes et inflammatoires, telles que la dermatite atopique, la polyarthrite rhumatoïde et la néphropathie lupique.
Bibliography:Application Number: WO2022US21284