NOVEL PHENYLAMINOPYRIMIDINE COMPOUND HAVING INHIBITORY ACTIVITY AGAINST LRRK2 AND USE THEREOF

• Main Authors: KIM, Seung Chan, SHIN, Jae Hong, SONG, Sang Ok, KO, Eun, KIM, Hyun Jin, LEE, Jaeyoung, CHO, Dae Hyun, KANG, Eunji
• Format: Patent
• Language: English; French; Korean
• Published: 29.09.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides a pyrimidine compound of chemical formula 1, a pharmaceutical composition containing same for preventing or treating a LRRK2-mediated or related disease (for example, Parkinson's disease), and a method for treating and preventing disorders or diseases by using same. Having inhibitory activity against LRRK2, the pyrimidine compound according to the present invention can be advantageously used for preventing or treating LRRK2-related diseases (for example, Parkinson's disease). La présente invention concerne un composé de pyrimidine de formule chimique 1, une composition pharmaceutique le contenant pour prévenir ou traiter une maladie médiée ou liée par/à LRRK2 (par exemple, la maladie de Parkinson), et un procédé de traitement et de prévention de troubles ou de maladies à l'aide de ceux-ci. Ayant une activité inhibitrice contre LRRK2, le composé de pyrimidine selon la présente invention peut être avantageusement utilisé pour prévenir ou traiter des maladies liées à LRRK2 (par exemple, la maladie de Parkinson). 본 발명은 화학식 1의 피리미딘 화합물, 이를 포함하는 LRRK2에 의해 매개되거나 이와 관련된 질병(예컨대, 파킨슨병)의 예방 또는 치료용 약학적 조성물, 및 이를 이용한 질병 또는 질환의 치료 및 예방 방법을 제공한다. 본 발명에 따른 피리미딘 화합물은 LRRK2 저해 활성이 우수하여 LRRK2와 관련된 질병(예컨대, 파킨슨병)의 예방 또는 치료에 효과적으로 사용될 수 있다.