B7-H3 ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF, AND USE THEREOF

• Main Authors: LEE, Jung Wook, PARK, Dong Woon, LEE, Jung Eun, JUNG, Byung Hun, KANG, Jung Hee
• Format: Patent
• Language: English; French; Korean
• Published: 29.09.2022
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to a B7-H3 antibody or an antigen-binding fragment thereof, and a use thereof, and more specifically to a B7-H3 antibody or an antigen-binding fragment thereof, and a use thereof, the B7-H3 antibody having a predetermined complementarity determining region, thereby specifically binding to a B7-H3 antigen, and being internalized into a cell, and being usable as an immune checkpoint inhibitor for various diseases. La présente invention concerne un anticorps B7-H3 ou un fragment de liaison à l'antigène de celui-ci, et son utilisation, et plus particulièrement un anticorps B7-H3 ou un fragment de liaison à l'antigène de celui-ci, et son utilisation, l'anticorps B7-H3 ayant une région de détermination de complémentarité déterminée, se liant ainsi de manière spécifique à un antigène B7-H3, et qui est internalisé dans une cellule, et qui peut être utilisé en tant qu'inhibiteur de point de contrôle immunitaire pour diverses maladies. 본 발명은 B7-H3 항체 또는 이의 항원 결합 단편 및 이의 용도에 관한 것으로서, 보다 상세하게는 소정의 상보성 결정 영역을 가짐으로써 B7-H3 항원에 특이적으로 결합하고 세포 내로 내재화되며 다양한 질환의 면역 관문 억제제로 활용될 수 있는, B7-H3 항체 또는 이의 항원 결합 단편 및 이의 용도에 관한 것이다.