COMPLEX COMPOSITION FOR PREVENTING OR TREATING HEARING LOSS CONTAINING SARPOGRELATE AND VACCINIUM MYRTILLUS EXTRACT AS ACTIVE INGREDIENTS

• Main Authors: SHIN, Sang Kyu, CHOI, Sook
• Format: Patent
• Language: English; French; Korean
• Published: 29.09.2022
• Subjects: FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The present invention relates to a complex composition for preventing or treating hearing loss, containing sarpogrelate and a Vaccinium myrtillus extract as active ingredients. The complex composition has been confirmed to effectively inhibit hair cell death by reactive oxygen species generated by hydrogen peroxide, in a small dose, and exhibit an excellent protective effect on zebrafish auditory hair cells, and therefore, the complex composition can be effectively used as a drug or health food for preventing or treating hearing loss. La présente invention concerne une composition complexe pour la prévention ou le traitement de la perte auditive, contenant du sarpogrelate et un extrait de Vaccinium myrtillus en tant que principes actifs. Il a été confirmé que la composition complexe inhibait efficacement la mort des cellules ciliées suscitée par des espèces réactives d'oxygène générées par le peroxyde d'hydrogène, à petite dose, et présentait un excellent effet protecteur sur les cellules ciliées auditives de poisson zèbre, et par conséquent, la composition complexe peut être efficacement utilisée en tant que médicament ou aliment diététique pour prévenir ou traiter la perte auditive. 본 발명은 사포그릴레이트 및 빌베리 추출물을 유효성분으로 함유하는 난청 예방 또는 치료용 복합조성물에 관한 것으로, 상기 복합조성물은 적은 용량으로 과산화수소에 의해 생성된 활성산소종에 의한 유모세포사멸을 효과적으로 억제하고, 제브라피시 청각유모 세포에 대한 우수한 보호 효과를 나타내는 것이 확인됨에 따라, 상기 복합조성물은 난청 예방 또는 치료용 약제 또는 건강식품으로 유용하게 활용될 수 있다.