FERRITIN VARIANTS WITH INCREASED STABILITY AND COMPLEXATION ABILITY

The present invention relates to a ferritin variant polypeptide, wherein at least one lysine residue is deleted or substituted with a non-basic amino acid. The invention further relates to a complex of this polypeptide and a label or drug, and an isolated cellular delivery system comprising the poly...

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Bibliographic Details
Main Authors BONAMORE, Alessandra, MARSZALEK, Ilona, SKORZYNSKI, Marcin, KROL, Magdalena, BOFFI, Alberto, RYGIEL, Tomasz, ARCOVITO, Alessandro
Format Patent
LanguageEnglish
French
Published 22.09.2022
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to a ferritin variant polypeptide, wherein at least one lysine residue is deleted or substituted with a non-basic amino acid. The invention further relates to a complex of this polypeptide and a label or drug, and an isolated cellular delivery system comprising the polypeptide or the complex of the invention as well as uses of such system for prophylaxis, therapy, diagnosis or theragnosis, in particular for therapy of cancer or inflammatory diseases. La présente invention concerne un polypeptide variant de ferritine, dans lequel au moins un résidu lysine est supprimé ou substitué par un acide aminé non basique. L'invention concerne en outre un complexe de ce polypeptide et d'une étiquette ou d'un médicament et un système d'administration cellulaire isolé comprenant le polypeptide ou le complexe de l'invention, ainsi que des utilisations de ce système pour la prophylaxie, la thérapie, le diagnostic ou la théragnostique, en particulier pour la thérapie d'un cancer ou de maladies inflammatoires.
Bibliography:Application Number: WO2022EP57205