SUSTAINED FORMULATION FOR PREVENTION OR TREATMENT OF AUTOIMMUNE DISEASE CONTAINING LOW-DOSE NALTREXONE AND METHOD USING SAME

• Main Authors: KIM, Donghoon, KIM, Ju Hee, LEE, Mase
• Format: Patent
• Language: English; French; Korean
• Published: 15.09.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Provided are: a sustained formulation, for prevention or treatment of an autoimmune disease, containing naltrexone or a pharmaceutically acceptable salt thereof, and microparticles comprising a biodegradable polymer; and a method using same. The present invention may be used for continuous and long-term prevention or treatment of an autoimmune disease by means of a single administration. La présente invention concerne : une formulation à libération prolongée, pour la prévention ou le traitement d'une maladie auto-immune, contenant de la naltrexone ou un sel pharmaceutiquement acceptable correspondant, et des microparticules comprenant un polymère biodégradable ; et une méthode utilisant ladite formulation. La présente invention peut être utilisée pour la prévention ou le traitement continu et à long terme d'une maladie auto-immune au moyen d'une administration unique. 날트렉손(naltrexone) 또는 그의 약학적으로 허용가능한 염, 및 생분해성 고분자를 포함하는 마이크로입자를 포함하는 자가면역질환 예방 또는 치료용 서방성 제제 및 이를 이용한 방법을 제공한다. 이에 따르면, 자가면역질환을 1회 투여로 장기지속적으로 예방 또는 치료하는데 이용할 수 있다.