HETEROBIFUNCTIONAL COMPOSITIONS FOR TARGETED PROTEIN DEGRADATION AND METHODS FOR THEIR USE

Compositions and methods for control and/or modification of endogenous protein degradation are described. The compositions are directed to heterobifunctional molecules having protein and enzyme system binding moieties linked together by an organic linker group. The compositions are selective for bin...

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Bibliographic Details
Main Authors PARKER, Christopher, FORREST, Ines, CONWAY, Louis, CHAHEINE, Christian
Format Patent
LanguageEnglish
French
Published 09.09.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Compositions and methods for control and/or modification of endogenous protein degradation are described. The compositions are directed to heterobifunctional molecules having protein and enzyme system binding moieties linked together by an organic linker group. The compositions are selective for binding to certain endogenous proteins and function to recruit endogenous decomposition systems such as the polyubiquitin system for peptide cleavage and reassimilation. L'invention concerne des compositions et des méthodes pour le contrôle et/ou la modification de la dégradation de protéines endogènes. Les compositions sont dirigées vers des molécules hétérobifonctionnelles ayant des fractions de liaison de protéine et de système enzymatique liées ensemble par un groupe de liaison organique. Les compositions sont sélectives pour se lier à certaines protéines endogènes et fonctionnent pour recruter des systèmes de décomposition endogènes tels que le système polyubiquitine pour le clivage et la réassimilation de peptides.
Bibliography:Application Number: WO2022US18944