TECHNIQUE FOR DIAGNOSING AND MONITORING NEURODEGENERATIVE DISEASES ON BASIS OF BODY FLUID ANALYSIS

• Main Authors: LIM, Jae Woo, LIM, Eun Kyung, KIM, Su Jin, JUNG, Ju Yeon, SON, Seong Uk, LEE, Kyu Sun, KANG, Tae Joon, MOON, Min Ho, SEO, Seung Beom, KANG, Byung Hoon
• Format: Patent
• Language: English; French; Korean
• Published: 01.09.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; VINEGAR; WINE

The present invention relates to a technique for diagnosing and monitoring neurodegenerative diseases on the basis of body fluid analysis. If a detection system of the present invention is used, effective real-time diagnostic efficiency can be exhibited while a problem such as noise is minimized. Particularly, since miRNAs present in trace amounts are detected in a high detection efficiency and are diagnosed, an excellent diagnostic effect on neurodegenerative diseases including Alzheimer's disease is exhibited. La présente invention concerne une technique de diagnostic et de surveillance de maladies neurodégénératives sur la base d'une analyse de fluide corporel. En utilisant un système de détection de la présente invention, il est possible de parvenir à un diagnostic efficace en temps réel tout en minimisant un problème tel que le bruit. En particulier, étant donné que les miRNA présents à l'état de traces sont détectés avec une efficacité de détection élevée et sont diagnostiqués, il en résulte un excellent effet diagnostique sur les maladies neurodégénératives, y compris la maladie d'Alzheimer. 본 발명은 체액 검사 기반 퇴행성 뇌질환 진단 및 모니터링 기술에 관한 것이다. 본 발명에 따른 검출 시스템을 이용하는 경우 노이즈 등의 문제를 최소화하면서 효과적인 실시간 진단 효율을 나타낼 수 있다. 특히, 미량으로 존재하는 miRNA를 높은 검출 효율로 검출하고 이를 진단함으로써 알츠하이머 병을 포함하는 퇴행성 뇌질환에 대한 우수한 진단 효과를 나타낸다.