IMIDAZO[1,2-A]PYRAZINES AS INHIBITORS OF HASPIN AND THERAPEUTIC USES THEREOF

The present invention relates to a group of compounds with an imidazo[1,2-a]pyrazine core of formula (I) which are inhibitors of HASPIN, whose activity is required for the proliferation of certain tumoral cells, so the compounds of the invention are useful for the prevention and/or treatment of canc...

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Main Authors GONZÁLEZ CANTALAPIEDRA, Esther, PASTOR FERNÁNDEZ, Joaquín, CEBRIÁ GÓMEZ, Antonio, PASTOR FERNÁNDEZ, Miryam, BLANCO-APARICIO, Carmen, ALBARRÁN SANTIÑO, María Isabel, MALUMBRES MARTÍNEZ, Marcos, GARCÍA GARCÍA, Ana Belén, MARTÍNEZ GONZÁLEZ, Sonia, HERNÁNDEZ HIGUERAS, Ana Isabel
Format Patent
LanguageEnglish
French
Published 01.09.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to a group of compounds with an imidazo[1,2-a]pyrazine core of formula (I) which are inhibitors of HASPIN, whose activity is required for the proliferation of certain tumoral cells, so the compounds of the invention are useful for the prevention and/or treatment of cancer alone or in combination with chemotherapeutic agents. La présente invention concerne un groupe de composés ayant un noyau imidazo[1,2-a]pyrazine de formule (I) qui sont des inhibiteurs de HASPIN, dont l'activité est requise pour la prolifération de certaines cellules tumorales, de sorte que les composés de l'invention sont utiles pour la prévention et/ou le traitement du cancer seuls ou en combinaison avec des agents chimiothérapeutiques.
Bibliography:Application Number: WO2022EP54626