SALT AND CRYSTAL FORMS OF AN HMOX1 INDUCER
Disclosed is the 1:1 phosphate salt of Compound (I) as well as a novel crystal form thereof. Also disclosed is a novel crystal form of Compound (I). The present invention also provides methods of increasing the activity of HMOX-1 in a subject, of activating transcription factor Nrf2 in a subject or...
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| Main Authors | , , |
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| Format | Patent |
| Language | English French |
| Published |
25.08.2022
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| Abstract | Disclosed is the 1:1 phosphate salt of Compound (I) as well as a novel crystal form thereof. Also disclosed is a novel crystal form of Compound (I). The present invention also provides methods of increasing the activity of HMOX-1 in a subject, of activating transcription factor Nrf2 in a subject or of reducing the amount of ROS in a subject by administering an effective amount of the 1:1 phosphate salt of Compound (I), the crystal form thereof or the crystal form of Compound (I) to the subject.
L'invention concerne un sel de phosphate 1 : 1 du composé (I) ainsi qu'une nouvelle forme cristalline de celui-ci. L'invention concerne également une nouvelle forme cristalline du composé (I). La présente invention concerne également des procédés permettant d'augmenter l'activité de HMOX-1 chez un sujet, d'activer le facteur de transcription Nrf2 chez un sujet ou de réduire la quantité de ROS chez un sujet par administration d'une quantité efficace du sel de phosphate 1 : 1 du composé (I), sa forme cristalline ou la forme cristalline du composé (I) au sujet. |
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| AbstractList | Disclosed is the 1:1 phosphate salt of Compound (I) as well as a novel crystal form thereof. Also disclosed is a novel crystal form of Compound (I). The present invention also provides methods of increasing the activity of HMOX-1 in a subject, of activating transcription factor Nrf2 in a subject or of reducing the amount of ROS in a subject by administering an effective amount of the 1:1 phosphate salt of Compound (I), the crystal form thereof or the crystal form of Compound (I) to the subject.
L'invention concerne un sel de phosphate 1 : 1 du composé (I) ainsi qu'une nouvelle forme cristalline de celui-ci. L'invention concerne également une nouvelle forme cristalline du composé (I). La présente invention concerne également des procédés permettant d'augmenter l'activité de HMOX-1 chez un sujet, d'activer le facteur de transcription Nrf2 chez un sujet ou de réduire la quantité de ROS chez un sujet par administration d'une quantité efficace du sel de phosphate 1 : 1 du composé (I), sa forme cristalline ou la forme cristalline du composé (I) au sujet. |
| Author | BIDDLE, Margaret KUANG, Shanming HU, Juan |
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| DocumentTitleAlternate | SELS ET FORMES CRISTALLINES D'UN INDUCTEUR HMOX1 |
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| Notes | Application Number: WO2022US17009 |
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| RelatedCompanies | MITOBRIDGE INC |
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| Snippet | Disclosed is the 1:1 phosphate salt of Compound (I) as well as a novel crystal form thereof. Also disclosed is a novel crystal form of Compound (I). The... |
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| Title | SALT AND CRYSTAL FORMS OF AN HMOX1 INDUCER |
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