SALT AND CRYSTAL FORMS OF AN HMOX1 INDUCER

Disclosed is the 1:1 phosphate salt of Compound (I) as well as a novel crystal form thereof. Also disclosed is a novel crystal form of Compound (I). The present invention also provides methods of increasing the activity of HMOX-1 in a subject, of activating transcription factor Nrf2 in a subject or...

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Bibliographic Details
Main Authors HU, Juan, BIDDLE, Margaret, KUANG, Shanming
Format Patent
LanguageEnglish
French
Published 25.08.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed is the 1:1 phosphate salt of Compound (I) as well as a novel crystal form thereof. Also disclosed is a novel crystal form of Compound (I). The present invention also provides methods of increasing the activity of HMOX-1 in a subject, of activating transcription factor Nrf2 in a subject or of reducing the amount of ROS in a subject by administering an effective amount of the 1:1 phosphate salt of Compound (I), the crystal form thereof or the crystal form of Compound (I) to the subject. L'invention concerne un sel de phosphate 1 : 1 du composé (I) ainsi qu'une nouvelle forme cristalline de celui-ci. L'invention concerne également une nouvelle forme cristalline du composé (I). La présente invention concerne également des procédés permettant d'augmenter l'activité de HMOX-1 chez un sujet, d'activer le facteur de transcription Nrf2 chez un sujet ou de réduire la quantité de ROS chez un sujet par administration d'une quantité efficace du sel de phosphate 1 : 1 du composé (I), sa forme cristalline ou la forme cristalline du composé (I) au sujet.
Bibliography:Application Number: WO2022US17009