ADENOVIRUS ENCODING 1L-15
A group B adenovirus comprising a sequence of formula 5'ITR-B1-BA-B2-BX-BB-BY-B3-3'ITR, wherein: By comprises a sequence -G1-G2n-G3m-G4p-G5q. G1 is a first transgene. G2 is a second transgene. G3 is a third transgene. G4 is a fourth transgene. G5 is a fifth transgene and IL-15 is encoded a...
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Main Authors | , |
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Format | Patent |
Language | English French |
Published |
18.08.2022
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Subjects | |
Online Access | Get full text |
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Summary: | A group B adenovirus comprising a sequence of formula 5'ITR-B1-BA-B2-BX-BB-BY-B3-3'ITR, wherein: By comprises a sequence -G1-G2n-G3m-G4p-G5q. G1 is a first transgene. G2 is a second transgene. G3 is a third transgene. G4 is a fourth transgene. G5 is a fifth transgene and IL-15 is encoded as a transgene in at least one of said locations, and characterised in that BY also encodes a polypeptide comprising the sushi domain of IL-15R alpha.
La présente invention concerne un adénovirus du groupe B comprenant une séquence de formule 5'ITR-B1-BA-B2-BX-BB-BY-B3-3'ITR, dans laquelle : BY comprend une séquence -G1-G2n-G3m-G4p-G5q. G1 est un premier transgène. G2 est un second transgène. G3 est un troisième transgène. G4 est un quatrième transgène. G5 est un cinquième transgène et IL-15 est codé en tant que transgène dans au moins l'un desdits emplacements, et caractérisé en ce que BY code en outre pour un polypeptide comprenant le domaine sushi d'IL-15 R alpha. |
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Bibliography: | Application Number: WO2022EP53477 |