ADENOVIRUS ENCODING 1L-15

A group B adenovirus comprising a sequence of formula 5'ITR-B1-BA-B2-BX-BB-BY-B3-3'ITR, wherein: By comprises a sequence -G1-G2n-G3m-G4p-G5q. G1 is a first transgene. G2 is a second transgene. G3 is a third transgene. G4 is a fourth transgene. G5 is a fifth transgene and IL-15 is encoded a...

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Bibliographic Details
Main Authors ZONCA, Manuela, CHAMPION, Brian Robert
Format Patent
LanguageEnglish
French
Published 18.08.2022
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A group B adenovirus comprising a sequence of formula 5'ITR-B1-BA-B2-BX-BB-BY-B3-3'ITR, wherein: By comprises a sequence -G1-G2n-G3m-G4p-G5q. G1 is a first transgene. G2 is a second transgene. G3 is a third transgene. G4 is a fourth transgene. G5 is a fifth transgene and IL-15 is encoded as a transgene in at least one of said locations, and characterised in that BY also encodes a polypeptide comprising the sushi domain of IL-15R alpha. La présente invention concerne un adénovirus du groupe B comprenant une séquence de formule 5'ITR-B1-BA-B2-BX-BB-BY-B3-3'ITR, dans laquelle : BY comprend une séquence -G1-G2n-G3m-G4p-G5q. G1 est un premier transgène. G2 est un second transgène. G3 est un troisième transgène. G4 est un quatrième transgène. G5 est un cinquième transgène et IL-15 est codé en tant que transgène dans au moins l'un desdits emplacements, et caractérisé en ce que BY code en outre pour un polypeptide comprenant le domaine sushi d'IL-15 R alpha.
Bibliography:Application Number: WO2022EP53477