USE OF ASCORBIC ACID AS STABILIZING AGENT FOR ANTI B7-H3 ANTIBODIES

The present invention relates to pharmaceutical compositions comprising a radiolabeled B7H3 antibody or antigen binding fragment thereof and ascorbic acid, methods for stabilizing pharmaceutical compositions and use of ascorbic acid as a stabilizing agent and/or a scavenger agent. La présente invent...

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Main Authors JENSEN, Andreas Ingeman, TRUMP, David, LUND-HANSEN, Torben, NAGEL, Johannes, THOE FØRSTER, Jon, KRAMER, Beth
Format Patent
LanguageEnglish
French
Published 11.08.2022
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Abstract The present invention relates to pharmaceutical compositions comprising a radiolabeled B7H3 antibody or antigen binding fragment thereof and ascorbic acid, methods for stabilizing pharmaceutical compositions and use of ascorbic acid as a stabilizing agent and/or a scavenger agent. La présente invention concerne des compositions pharmaceutiques comprenant un anticorps B7H3 radiomarqué ou un fragment de liaison à l'antigène de celui-ci et de l'acide ascorbique, des méthodes de stabilisation de compositions pharmaceutiques et l'utilisation de l'acide ascorbique en tant qu'agent stabilisant et/ou agent de piégeage.
AbstractList The present invention relates to pharmaceutical compositions comprising a radiolabeled B7H3 antibody or antigen binding fragment thereof and ascorbic acid, methods for stabilizing pharmaceutical compositions and use of ascorbic acid as a stabilizing agent and/or a scavenger agent. La présente invention concerne des compositions pharmaceutiques comprenant un anticorps B7H3 radiomarqué ou un fragment de liaison à l'antigène de celui-ci et de l'acide ascorbique, des méthodes de stabilisation de compositions pharmaceutiques et l'utilisation de l'acide ascorbique en tant qu'agent stabilisant et/ou agent de piégeage.
Author LUND-HANSEN, Torben
JENSEN, Andreas Ingeman
KRAMER, Beth
THOE FØRSTER, Jon
NAGEL, Johannes
TRUMP, David
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DocumentTitleAlternate UTILISATION D'ACIDE ASCORBIQUE COMME AGENT STABILISANT POUR DES ANTICORPS ANTI-B7-H3
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RelatedCompanies Y-MABS THERAPEUTICS, INC
J. MØLLER SAN-PEDRO, Claus
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Snippet The present invention relates to pharmaceutical compositions comprising a radiolabeled B7H3 antibody or antigen binding fragment thereof and ascorbic acid,...
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SubjectTerms CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title USE OF ASCORBIC ACID AS STABILIZING AGENT FOR ANTI B7-H3 ANTIBODIES
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