USE OF ASCORBIC ACID AS STABILIZING AGENT FOR ANTI B7-H3 ANTIBODIES

The present invention relates to pharmaceutical compositions comprising a radiolabeled B7H3 antibody or antigen binding fragment thereof and ascorbic acid, methods for stabilizing pharmaceutical compositions and use of ascorbic acid as a stabilizing agent and/or a scavenger agent. La présente invent...

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Bibliographic Details
Main Authors JENSEN, Andreas Ingeman, TRUMP, David, LUND-HANSEN, Torben, NAGEL, Johannes, THOE FØRSTER, Jon, KRAMER, Beth
Format Patent
LanguageEnglish
French
Published 11.08.2022
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to pharmaceutical compositions comprising a radiolabeled B7H3 antibody or antigen binding fragment thereof and ascorbic acid, methods for stabilizing pharmaceutical compositions and use of ascorbic acid as a stabilizing agent and/or a scavenger agent. La présente invention concerne des compositions pharmaceutiques comprenant un anticorps B7H3 radiomarqué ou un fragment de liaison à l'antigène de celui-ci et de l'acide ascorbique, des méthodes de stabilisation de compositions pharmaceutiques et l'utilisation de l'acide ascorbique en tant qu'agent stabilisant et/ou agent de piégeage.
Bibliography:Application Number: WO2022DK50018