ANTIBODY COMBINATION THERAPIES FOR SARS-COV-2 INFECTION

The present disclosure provides antibody combinations and related methods for treating a SARS-CoV-2 infection in a subject or for manufacturing a medicament for the treatment of a SARS-CoV-2 infection. In some aspects, a therapy, composition, or combination can include two or three antibodies that b...

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Main Authors LEMPP, Florian, YEH, Wendy, CORTI, Davide, MOGALIAN, Erik, JONES, Bryan Edward, HEBNER, Christy M, VIRGIN, Herbert W, PANG, Phillip S, ADAMS, Andrew Charles
Format Patent
LanguageEnglish
French
Published 28.07.2022
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present disclosure provides antibody combinations and related methods for treating a SARS-CoV-2 infection in a subject or for manufacturing a medicament for the treatment of a SARS-CoV-2 infection. In some aspects, a therapy, composition, or combination can include two or three antibodies that bind to different epitopes on a SARS-CoV-2 surface (S) glycoprotein. The antibody combinations can potently neutralize SARS-CoV-2. Antibody compositions comprising such combinations are also provided. La présente divulgation concerne des combinaisons d'anticorps et des méthodes associées pour traiter une infection par SARS-CoV-2 chez un sujet ou pour fabriquer un médicament pour le traitement d'une infection par SARS-CoV-2. Dans certains aspects, une thérapie, une composition ou une combinaison peuvent comprendre deux ou trois anticorps qui se lient à différents épitopes sur une glycoprotéine de surface (S) de SARS-CoV-2. Les combinaisons d'anticorps peuvent neutraliser puissamment le SARS-CoV-2. L'invention concerne également des compositions d'anticorps comprenant de telles combinaisons.
Bibliography:Application Number: WO2022US13568