INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS

The present invention is directed to indazole and azaindazole derivatives of formulae as shown below which are inhibitors of LRRK2 and are useful in the treatment of CNS disorders such as Parkinson's disease. La présente invention a pour objet des dérivés d'indazole et d'azaindazole d...

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Main Authors BERNARDI, Silvia, GAROFALO, Albert W, SCHWARZ, Jacob Bradley, BUDASSI, Federica, SABBATINI, Fabio Maria, MIGLIORE, Marco
Format Patent
LanguageEnglish
French
Published 21.07.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention is directed to indazole and azaindazole derivatives of formulae as shown below which are inhibitors of LRRK2 and are useful in the treatment of CNS disorders such as Parkinson's disease. La présente invention a pour objet des dérivés d'indazole et d'azaindazole de formules telles que représentées dans la description, qui sont des inhibiteurs de LRRK2 et sont utiles dans le traitement de troubles du SNC tels que la maladie de Parkinson.
Bibliography:Application Number: WO2022US12437