PROCESS FOR THE PREPARATION OF HIGH PURITY LEVOSIMENDAN

An improved process for the preparation of high purity Levosimendan includes treatment of Levosimendan crude with an organic acid, adding an organic acid to precipitate Levosimendan and isolating pure Levosimendan from the precipitate. Levosimendan obtained by the improved process is pharmaceuticall...

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Bibliographic Details
Main Authors JEYAKUMAR, John Muthiah Raja, BHATT, Chiragkumar Anilkumar, PANDYA, Keyurkumar Amrutla, PARMAR, Pankaj Vasudev
Format Patent
LanguageEnglish
French
Published 14.07.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:An improved process for the preparation of high purity Levosimendan includes treatment of Levosimendan crude with an organic acid, adding an organic acid to precipitate Levosimendan and isolating pure Levosimendan from the precipitate. Levosimendan obtained by the improved process is pharmaceutically acceptable with no impurity higher than 0.2 percent. Un procédé amélioré pour la préparation de lévosimendan de pureté élevée comprend le traitement lévosimendan brut avec un acide organique, l'ajout d'un acide organique pour précipiter le lévosimendan et l'isolement du lévosimendan pur à partir du précipité. Le lévosimendan obtenu par le procédé amélioré est pharmaceutiquement acceptable et ne présente pas plus de 0,2 pour cent d'impureté.
Bibliography:Application Number: WO2022US11965