MODIFIED NUCLEIC ACID CONJUGATES

• Main Authors: HILLER, Thomas, KURRECK, Jens, SHAEF, Ida, FECHLER BITTETI, Mona, FUCHS, Merle
• Format: Patent
• Language: English; French
• Published: 07.07.2022
• Subjects: CHEMISTRY; DERIVATIVES THEREOF; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; SUGARS

The present invention refers to a nucleic acid conjugate comprising at least one 2',3´-O ketal moiety. This conjugate is suitable for the target-specific or target-selective delivery of nucleic acid molecules into cells such as mammalian cells including human cells with high efficacy. Thus, a n...