NITROGEN CONTAINING 2,3-DIHYDROQUINAZOLINONE COMPOUNDS AS NAV1.8 INHIBITORS

• Main Authors: ELBAN, Mark Andrew, DONG, Xiaoyang, HOANG, Tram H, GUANG, Jie, HO, Ming-Hsun, ROMANO, Joseph J, WASHBURN, David Glenn
• Format: Patent
• Language: English; French
• Published: 23.06.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Compounds of formula (I) are described, wherein each of the variable groups is as defined in the specification. Also described are pharmaceutical compositions containing a compound of formula (I), and uses of the compounds and pharmaceutical compositions for inhibiting Nav1.8 voltage-gated sodium channels and treating Nav1.8 mediated diseases, disorders, and conditions, such as pain and pain-associated diseases, disorders, and conditions and cardiovascular diseases, disorders, and conditions, such as atrial fibrillation. L'invention concerne des composés de formule (I), chacun des groupes variables étant tel que défini dans la description. L'invention concerne également des compositions pharmaceutiques contenant un composé de formule (I), et des utilisations des composés et des compositions pharmaceutiques pour inhiber les canaux sodiques sensibles à la tension Nav1.8 et traiter des maladies médiées par Nav1.8, des troubles et des états, tels que la douleur et des maladies, des troubles et des états associés à la douleur, et des maladies, des troubles et des états cardiovasculaires, tels que la fibrillation auriculaire.