ANTIVIRAL COMPOSITION CONTAINING FUCOSYLLACTOSE AS ACTIVE INGREDIENT

• Main Authors: SHIN, Chul Soo, MOON, Seok Oh, YOON, Jong Won, YOO, Jong Gil, SONG, Young Ha, MOON, Jung Hee, KWEON, Dae Hyuk, JEON, Seon Min
• Format: Patent
• Language: English; French; Korean
• Published: 16.06.2022
• Subjects: FODDER; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The present invention relates to the antiviral and viral infection-inhibitory effects of fucosyllactose. According to the present invention, 2'-fucosyllactose and 3-fucosyllactose, which are human milk oligosaccharides (HMOs), were confirmed to have antiviral activity, and in particular, 3-fucosyllactose was found in vitro and in vivo to have significant antiviral activity and inhibitory efficacy against viral infection compared to 2'-fucosyllactose, and thus can be effectively used for antiviral purposes. La présente invention concerne les effets antiviraux et inhibiteurs d'infection virale du fucosyllactose. Selon la présente invention, il a été confirmé que le 2'-fucosyllactose et le 3-fucosyllactose, qui sont des oligosaccharides du lait humain (HMO), présentent une activité antivirale, et en particulier, il a été découvert que le 3-fucosyllactose, in vitro et in vivo, présente une activité antivirale et une efficacité inhibitrice contre une infection virale significatives par rapport au 2'-fucosyllactose, et peuvent ainsi être utilisés efficacement à des fins antivirales. 본 발명은 푸코실락토스의 항바이러스 및 바이러스 감염 억제 효과에 관한 것으로, 본 발명에 따르면, 인간 모유 올리고당(human milk oligosaccharides, HMOs)인 2'-푸코실락토스 및 3-푸코실락토스는 항바이러스 활성을 가지는 것으로 확인되었으며, 특히, 3-푸코실락토스는 2'-푸코실락토스에 비해 현저한 항바이러스 활성 및 바이러스 감염 억제능을 가지는 것을 in vitro 및 in vivo로 밝혔으므로, 이를 항바이러스 용도로 유용하게 활용할 수 있다.