ANTI-OX40L ANTIBODY, ANTI-OX40L/ANTI-TNFα BISPECIFIC ANTIBODY, AND USES THEREOF

• Main Authors: PARK, Bum Chan, PARK, Jae Eun, HA, Gyong Sik, LEE, Hyun Mi, CHO, Kyu Eun, JUNG, Seung Hee, LEE, Yoon Jung, CHOI, Jong Ryoul, LEE, Chung Min, KANG, Hyeon Ju, KIM, Soo Young, SHIM, Eun Young, YOO, Jung Min
• Format: Patent
• Language: English; French; Korean
• Published: 16.06.2022
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TESTING

The present invention relates to a novel antibody that specifically binds to OX40L and a bispecific antibody that specifically binds to OX40L and TNFα and, in particular, to: an antibody or a bispecific antibody that specifically binds to human OX40L to effectively inhibit the binding between OX40 and an OX40 receptor; a nucleic acid encoding the antibody; an expression vector comprising the nucleic acid; a transformant comprising the expression vector; a method for producing the antibody; a pharmaceutical composition for the treatment of autoimmune diseases or inflammatory diseases, comprising the antibody; a composition for the diagnosis of autoimmune diseases or inflammatory diseases, comprising the antibody; a method for diagnosing autoimmune diseases or inflammatory diseases by using the antibody; and a method for providing information for the diagnosis of autoimmune diseases or inflammatory diseases by using the antibody; and a kit for providing same. La présente invention concerne un nouvel anticorps qui se lie de manière spécifique à OX40L et un anticorps bispécifique qui se lie de manière spécifique à OX40L et TNFα et, en particulier : un anticorps ou un anticorps bispécifique qui se lie de manière spécifique à OX40L humain pour inhiber efficacement la liaison entre OX40 et un récepteur OX40 ; un acide nucléique codant pour l'anticorps ; un vecteur d'expression comprenant l'acide nucléique ; un transformant comprenant le vecteur d'expression ; un procédé de production de l'anticorps ; une composition pharmaceutique pour le traitement de maladies auto-immunes ou de maladies inflammatoires, comprenant l'anticorps ; une composition pour le diagnostic de maladies auto-immunes ou de maladies inflammatoires, comprenant l'anticorps ; un procédé de diagnostic de maladies auto-immunes ou de maladies inflammatoires à l'aide de l'anticorps ; et un procédé pour fournir des informations pour le diagnostic de maladies auto-immunes ou de maladies inflammatoires à l'aide de l'anticorps ; et un kit pour une mise en œuvre correspondante. 본 발명은 OX40L에 특이적으로 결합하는 신규한 항체 및 OX40L와 TNFα에 특이적으로 결합하는 이중 특이성 항체에 관한 것으로, 구체적으로는 인간 OX40L에 특이적으로 결합하여 OX40와 OX40 수용체와의 결합을 효과적으로 저해하는 항체 또는 이중 특이성 항체, 상기 항체를 코딩하는 핵산, 상기 핵산을 포함하는 발현벡터, 상기 발현 벡터를 포함하는 형질전환체, 상기 항체의 제조방법, 상기 항체를 포함하는 자가면역질환 또는 염증성 질환의 치료용 약학적 조성물, 상기 항체를 포함하는 자가면역질환 또는 염증성 질환의 진단용 조성물, 상기 항체를 이용한 자가면역질환 또는 염증성의 진단 방법 및 상기 항체를 이용한 자가면역질환 또는 염증성질환의 진단을 위한 정보의 제공 방법 및 이를 제공하기 위한 키트에 관한 것이다.