DESIGNED BACTERIAL COMPOSITIONS FOR TREATING GRAFT-VERSUS-HOST-DISEASE

• Main Authors: FORD, Christopher B, HALVORSEN, Elizabeth, HENN, Matthew R, VULIC, Marin, PIÑA, Ambar, BARDHAN, Kankana, NANDAKUMAR, Madhumitha, DATTA, Sumon, KIESER, Karen, LOMBARDO, Mary-Jane, O'BRIEN, Edward J, SALEH, Mahmoud, MARTINEZ, Asuncion, NARENDAR, Priyanka, BALASUBRAMANIAN, Divya
• Format: Patent
• Language: English; French
• Published: 02.06.2022
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; FISHING; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; FORESTRY; HUMAN NECESSITIES; HUNTING; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES; TRAPPING

Provided herein are bacterial compositions that are useful for treating and preventing complications and side effects associated with a disease or disorder, such as those associated with immune suppression, including infections and/or GvHD, for example, in HSCT subjects. The bacterial compositions disclosed herein are designed to exhibit one or more functional features that are useful for the treatment of such diseases and disorders. L'invention concerne des compositions bactériennes qui sont utiles pour traiter et prévenir des complications et des effets secondaires associés à une maladie ou un trouble, tels que ceux associés à la suppression immunitaire, y compris des infections et/ou la GvHD, par exemple, chez des sujets HSCT. Les compositions bactériennes de l'invention sont conçues pour présenter une ou plusieurs caractéristiques fonctionnelles qui sont utiles pour le traitement de tels troubles et maladies.