ANTIGEN SPECIFIC T CELLS AND METHODS OF MAKING AND USING SAME

In various embodiments, the present disclosure provides T cell compositions comprising T cells that encode and/or express a T cell receptor (TCR) that binds to a neoantigen associated with a subject's cancer, and are useful for adoptive immunotherapy. Also disclosed are methods for making and/o...

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Bibliographic Details
Main Authors BARRY, Walter, SLANETZ, Alfred E
Format Patent
LanguageEnglish
French
Published 14.07.2022
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:In various embodiments, the present disclosure provides T cell compositions comprising T cells that encode and/or express a T cell receptor (TCR) that binds to a neoantigen associated with a subject's cancer, and are useful for adoptive immunotherapy. Also disclosed are methods for making and/or using T cell compositions described herein. Dans divers modes de réalisation, la présente divulgation concerne des compositions de lymphocytes T comprenant des lymphocytes T qui codent et/ou expriment un récepteur de lymphocytes T (TCR) qui se lie à un néo-antigène associé au cancer d'un sujet, et qui sont utiles pour une immunothérapie adoptive. La divulgation concerne également des méthodes de préparation et d'utilisation de ces compositions de lymphocytes T.
Bibliography:Application Number: WO2021US60873