SOLID FORMS OF 4-(5-(4-FLUOROPHENYL)-6-TETRAHYDRO-2H-PYRAN-4-YL)- 1,5-DIHYDROPYRROLO[2,3-F]INDAZOL-7-YL)BENZOIC ACID

Solid forms of 4-(5-(4-fluorophenyl)-6-(tetrahydro-2H-pyran-4-yl)-1,5-dihydropyrrolo[2,3-f]indazol-7-yl)benzoic acid (Compound 1) capable of modulating alpha-1 antitrypsin (AAT) activity and methods of treating alpha-1 antitrypsin deficiency (AATD) by administering one or more such forms, and method...

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Main Authors SPOSATO, Marisa, SONG, Zhengtian, TORRICO GUZMAN, Elisa, MEDEK, Ales, RODAY, Setu, SOKOLOWSKY, Kathleen, HU, Kan-Nian, LAI, Mei-Hsiu, SAWANT, Rupa, LIU, Siying, OVERHOFF, Kirk, GIROUX, Simon, SHI, Yi
Format Patent
LanguageEnglish
French
Published 30.06.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Solid forms of 4-(5-(4-fluorophenyl)-6-(tetrahydro-2H-pyran-4-yl)-1,5-dihydropyrrolo[2,3-f]indazol-7-yl)benzoic acid (Compound 1) capable of modulating alpha-1 antitrypsin (AAT) activity and methods of treating alpha-1 antitrypsin deficiency (AATD) by administering one or more such forms, and methods of using and preparing the same for treatment of alpha-1 antitrypsin deficiency (AATD). La présente invention concerne des formes solides de l'acide 4-(5-(4-fluorophényl)-6-(tétrahydro-2H-pyran-4-yl)-1,5-dihydropyrrolo[2,3-f]indazol-7-yl)benzoïque (composé 1) capables de moduler l'activité de l'alpha-1-antitrypsine (AAT) et des méthodes de traitement d'une déficience en alpha-1-antitrypsine (AATD) par l'administration d'une ou plusieurs de telles formes, et des méthodes d'utilisation et des procédés de préparation de celles-ci pour le traitement d'une déficience en alpha-1-antitrypsine (AATD).
Bibliography:Application Number: WO2021US72451