EXPRESSION TECHNOLOGY FOR ANTIBODY CONSTRUCTS

The present invention pertains to expression vector designs for antibody constructs. Different polypeptide chains of an antibody construct are encoded within the same open reading frame, connected to each other by a 2A peptide linker. This expression vector design leads to homogeneous expression and...

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Bibliographic Details
Main Authors CHELUR, Dattananda, RITTER, Anett, HESSLING, Martin
Format Patent
LanguageEnglish
French
Published 27.05.2022
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The present invention pertains to expression vector designs for antibody constructs. Different polypeptide chains of an antibody construct are encoded within the same open reading frame, connected to each other by a 2A peptide linker. This expression vector design leads to homogeneous expression and correct assembly of the antibody construct. La présente invention concerne des conceptions de vecteurs d'expression pour constructions d'anticorps. Différentes chaînes polypeptidiques d'une construction d'anticorps sont codées dans le même cadre de lecture ouvert, reliées l'une à l'autre par un lieur peptidique 2A. Cette conception de vecteur d'expression conduit à une expression homogène et à un assemblage correct de la construction d'anticorps.
Bibliography:Application Number: WO2021IB60796