PYRAZOLE DERIVATIVES AS RET KINASE INHIBITORS

Disclosed herein are compounds of formula I: or a pharmaceutically acceptable salt thereof, where the variables are as defined herein. These compounds are useful in treating RET associated cancers. Formulations containing the compounds of formula I and methods of making the compounds of formula I ar...

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Main Authors PANCALDI, Thomas, KOLAKOWSKI, Gabrielle, BOLDRON, Christopher, MCKENNEY, Megan, CONDROSKI, Kevin, MUNCHHOF, Michael, ANDERSON, Erin, ANDREWS, Steven, IRVIN, Thomas, KUMAR, Manoj, MCFADDIN, Elizabeth, MCLEAN, Johnathan, PINTO, Marta, MOURET, Tiphaine, PILKINGTON-MIKAS, Michael
Format Patent
LanguageEnglish
French
Published 27.04.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed herein are compounds of formula I: or a pharmaceutically acceptable salt thereof, where the variables are as defined herein. These compounds are useful in treating RET associated cancers. Formulations containing the compounds of formula I and methods of making the compounds of formula I are also disclosed. L'invention concerne des composés de formule I : ou un sel pharmaceutiquement acceptable de ceux-ci, les variables étant telles que définies dans la description. Ces composés sont utiles dans le traitement de cancers associés à RET. L'invention concerne également des formulations contenant les composés de formule I et des procédés de préparation des composés de formule I.
Bibliography:Application Number: WO2021US58206