DIAMINOPYRIMIDINE CARBOXAMIDE INHIBITORS OF HPK1

Compounds of the formula I: or the pharmaceutically acceptable salts thereof, are inhibitors of haematopoietic progenitor kinase 1 (HPK1) useful in the treatment of diseases or disorders associated with HPK1. Also disclosed herein are uses of these compounds in the potential treatment or prevention...

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Main Authors NAIR, Anilkumar G, VARA, Brandon A, CANDITO, David A, LI, Bing, ACHAB, Abdelghani, DONOFRIO, Anthony, YU, Elsie C, FRADERA, Xavier, KAWAMURA, Shuhei, PASTERNAK, Alexander, LEVI, Samuel M
Format Patent
LanguageEnglish
French
Published 12.05.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Compounds of the formula I: or the pharmaceutically acceptable salts thereof, are inhibitors of haematopoietic progenitor kinase 1 (HPK1) useful in the treatment of diseases or disorders associated with HPK1. Also disclosed herein are uses of these compounds in the potential treatment or prevention of an HPK1-associated disease or disorder. Also disclosed herein are compositions comprising one or more of the compounds. Further disclosed herein are uses of these compositions in the potential prevention or treatment of an HPK1-associated disease or disorder. L'invention concerne des composés de formule I : ou des sels pharmaceutiquement acceptables correspondants qui sont des inhibiteurs de la kinase-1 hématopoïétique progénitrice (HPK1) utiles dans le traitement de maladies ou de troubles associés à HPK1. Des utilisations de ces composés dans le traitement potentiel ou la prévention potentielle d'une maladie ou d'un trouble associé à HPK-1 sont également divulguées. Des compositions comprenant un ou plusieurs des composés sont également divulguées. Des utilisations de ces compositions dans le traitement ou la prévention potentiels d'une maladie ou d'un trouble associé à HPK1 sont en outre divulguées.
Bibliography:Application Number: WO2021US57971