REACTIVE CONJUGATES

The present invention relates to compounds (reactive conjugates) for the chemical modification of therapeutic antibodies or proteins. The compounds enable the regioselective attachment of payloads to an antibody or antibody fragment in one single step, thereby producing a modified antibody or modifi...

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Bibliographic Details
Main Authors PANTIN, Mathilde Lucile Colette, LEVY, Frederic, NYANGUILE, Origéne Franz, SEGURA, Jean-Manuel, MARX, Léo, GARROUSTE, Patrick, POSTUPALENKO, Viktoriia
Format Patent
LanguageEnglish
French
Published 21.04.2022
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to compounds (reactive conjugates) for the chemical modification of therapeutic antibodies or proteins. The compounds enable the regioselective attachment of payloads to an antibody or antibody fragment in one single step, thereby producing a modified antibody or modified antibody fragment, which can be used for diagnosing, monitoring, imaging or treating disease. La présente invention concerne des composés (conjugués réactifs) pour la modification chimique d'anticorps ou de protéines thérapeutiques. Les composés permettent la fixation régiosélective de charges utiles à un anticorps ou un fragment d'anticorps en une seule étape, ce qui permet de produire un anticorps modifié ou un fragment d'anticorps modifié, qui peut être utilisé pour diagnostiquer, surveiller, imager ou traiter une maladie.
Bibliography:Application Number: WO2021EP78181