DEVELOPMENT AND APPLICATION OF POLYMER-COATED GOLD NANOPARTICLE-APTAMER NANOCONSTRUCT HAVING SENSITIVITY TO REACTIVE OXYGEN SPECIES

• Main Authors: PARK, Hyeong Mok, KIM, Won Jong, KIM, Jin Seong
• Format: Patent
• Language: English; French; Korean
• Published: 14.04.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present invention relates to a polymer-coated gold nanoparticle-aptamer nanoconstruct that has sensitivity to reactive oxygen species and can treat inflammatory diseases by the capture of reactive oxygen species and TNF-α. La présente invention concerne une nanoconstruction du type aptamère-nanoparticule d'or revêtue de polymère qui présente une sensibilité vis-à-vis de dérivés réactifs de l'oxygène (ROS) et qui peut traiter des maladies inflammatoires par capture de dérivés réactifs de l'oxygène et de TNF-α. 본 발명은 활성산소종 감응성을 가지고, 활성산소종 포집 및 TNF-α 포집을 통해 염증성 질환을 치료할 수 있는, 고분자가 코팅된 금 나노입자-압타머 나노구조체에 관한 것이다.