THERAPEUTIC USE, FOR NEURODEGENERATIVE DISEASES, OF TRIPLE AGONIST HAVING ACTIVITY WITH RESPECT TO ALL OF GLUCAGON, GLP-1, AND GIP RECEPTORS, OR CONJUGATE THEREOF

• Main Authors: LEE, Sang Hyun, LEE, A Ram, KIM, Jeong A
• Format: Patent
• Language: English; French; Korean
• Published: 31.03.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to a therapeutic use, for neurodegenerative diseases, of a triple agonist and/or a long-acting conjugate thereof, the triple agonist having activity with respect to a glucagon receptor, a glucagon-like peptide-1 (GLP-1) receptor, and a glucose-dependent insulinotropic polypeptide (GIP) receptor, and the present invention can expand options for patients by expanding the category of drugs applicable to neurodegenerative diseases, and can increase convenience for patients by significantly increasing blood half-life. La présente invention concerne un usage thérapeutique, pour des maladies neurodégénératives, d'un triple agoniste et/ou d'un conjugué à action prolongée de celui-ci, le triple agoniste ayant une activité par rapport à un récepteur du glucagon, un récepteur de peptide-1 ressemblant au glucagon (GLP-1) et un récepteur de polypeptide insulinotrope dépendant du glucose (GIP), et la présente invention peut étendre des options pour des patients en élargissant la catégorie de médicaments applicables à des maladies neurodégénératives, et peut augmenter la commodité pour des patients en augmentant significativement la demi-vie du sang. 본 발명은 글루카곤 수용체， GLP- 1 (Glucagon-like peptide- 1)수용체，및 GIP(Glucose-dependent insulinotropic polypeptide)수용 체에 대해 활성을 갖는 삼중 활성체 및/또는 이의 지속형 결합체의 신경퇴 행성 질환에 대한 치료적 용도에 관한 것으로，신 경퇴행성 질환에 적용 가능한 약물의 카테고리를 확장함으로써 환자들의 선택권을 넓힐 수 있으며，혈중 반감기를 현저하 게 증가시켜 환자들의 편리성을 증대시킬 수 있다.