SYNTHESIS METHOD FOR PREPARING SGLT INHIBITOR INTERMEDIATE

A method for preparing compound 1 and compound 2. The structures of the compound 1 and the compound 2 is shown below, and the method comprises the following steps: 1) taking 2,3-dihydrobenzofuran-7-aniline as a raw material, and carrying out selective dibromination by using a bromination reagent to...

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Bibliographic Details
Main Authors HUANG, Zhining, TANG, Jian, WANG, Junjing, ZHOU, Zhangtao, PHILLIS, Andrew Toroa, YE, Weiping
Format Patent
LanguageChinese
English
French
Published 17.03.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:A method for preparing compound 1 and compound 2. The structures of the compound 1 and the compound 2 is shown below, and the method comprises the following steps: 1) taking 2,3-dihydrobenzofuran-7-aniline as a raw material, and carrying out selective dibromination by using a bromination reagent to obtain 4,6-dibromo-2,3-dihydrobenzofuran-7-aniline; 2) enabling the 4,6-dibromo-2,3-dihydrobenzofuran-7-aniline obtained in the step 1) to be subjected to a Sandmeyer reaction for chlorination to obtain 4,6-dibromo-7-chloro-2,3-dihydrobenzofuran; 3-1) using a strong base to selectively remove bromine from the 4,6-dibromo-7-chloro-2,3-dihydrobenzofuran obtained in the step 2), and then adding a formylation reagent to obtain the compound 1; and 3-2) using a strong base to selectively remove bromine from the 4,6-dibromo-7-chloro-2,3-dihydrobenzofuran obtained in the step 2), and then performing reaction with 4-cyclopropyl benzaldehyde to obtain the compound 2. L'invention concerne un procédé de préparation du composé
Bibliography:Application Number: WO2020CN114471