DOSING FOR TREATMENT WITH ANTI-TIGIT AND ANTI-PD-L1 ANTAGONIST ANTIBODIES

• Main Authors: CHA, Edward Namserk, BARAK, Hila, ZHANG, Xiaosong, MENG, Raymond, CHAN, Hui Min Phyllis, HOANG, Tien, WU, Benjamin, MENDUS, Diana, STEVENS, Heather Blythe, LAU, Janet
• Format: Patent
• Language: English; French
• Published: 10.03.2022
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides methods of dosing for the treatment of cancers. In particular, provided are methods, compositions, uses, and kits for treating subjects having cancer by administering an anti-TIGIT antagonist antibody (e.g., an anti-TIG IT antagonist antibody as disclosed herein, e.g., tiragolumab) and a PD-1 axis binding antagonist (e.g., an anti-PD-L1 antagonist antibody (e.g., atezolizumab)). L'invention concerne des méthodes de dosage pour le traitement des cancers. En particulier, l'invention concerne des méthodes, des compositions, des utilisations et des trousses pour le traitement de sujets atteints de cancer par l'administration d'un anticorps antagoniste anti-TIGIT (p. ex. un anticorps antagoniste anti-TIG IT tel que décrit ici, p. ex. le tiragolumab) et d'un antagoniste de liaison à l'axe PD-1 (p. ex. un anticorps antagoniste anti-PD-L1, p. ex. l'atézolizumab).