APPLICATION OF SESQUITERPENE LACTONE IN PREPARING DRUG FOR TREATING OPTIC NEURITIS

• Main Authors: BAO, Shiqi, LI, Hongen, GONG, Jianmiao, ZHANG, Xuemei
• Format: Patent
• Language: Chinese; English; French
• Published: 03.03.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

An application of a sesquiterpene lactone compound in preparing a drug for treating optic neuritis, the sesquiterpene lactone compound and a pharmaceutically acceptable auxiliary material are prepared into a drug. The present study found that ACT001 can effectively inhibit the inflammatory response of microglia, and can significantly reduce the release of inflammatory factors, comprising NO, TNF-α, and IL-6. The present invention has the effect of inhibiting the proliferation of BV2 cells. The present invention also has a good curative effect on optic neuritis, particularly neuromyelitis optica. L'invention concerne une application d'un composé de lactone sesquiterpénique dans la préparation d'un médicament pour le traitement de la névrite optique, le composé de lactone sesquiterpénique et un matériau auxiliaire pharmaceutiquement acceptable étant préparés en médicament. La présente invention a découvert que ACT001 peut inhiber efficacement la réponse inflammatoire de la microglie, et peut réduire de manière