COMPOSITION FOR PREVENTION AND TREATMENT OF MYOPATHY

• Main Author: KIM, Yi-Rang
• Format: Patent
• Language: English; French; Korean
• Published: 17.02.2022
• Subjects: FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The present invention relates to a pharmaceutical composition comprising calcium pantothenate, or calcium pantothenate and dimenhydrinate as active ingredients for prevention and treatment of myopathy. According to the present disclosure, calcium pantothenate upregulates the expression of MHC, myogenin 4-EBP, and p70S6K to promote myoblast differentiation and myogenesis, thereby prolonging the duration of life in amyotrophic lateral sclerosis patients and promoting the growth of MSC in Duchenne muscular dystrophy mice. Such effects are synergistically increased upon combined treatment with dimenhydrinate. Thus, they can be advantageously used for preventing or treating myopathy. La présente invention porte sur une composition pharmaceutique comprenant du pantothénate de calcium, ou du pantothénate de calcium et du diménhydrinate en tant que principes actifs pour la prévention et le traitement de la myopathie. Selon la présente divulgation, le pantothénate de calcium régule à la hausse l'expression du CMH, de la myogénine 4-EBP, et de p70S6K pour favoriser la différenciation et la myogenèse des myoblastes, ce qui permet de prolonger la durée de vie chez les patients atteints de sclérose latérale amyotrophique et de favoriser la croissance des CSM chez les souris atteintes de dystrophie musculaire de Duchenne. De tels effets sont augmentés de manière synergique avec une polythérapie comprenant du diménhydrinate. Ainsi, ceux-ci peuvent être avantageusement utilisés pour prévenir ou traiter la myopathie. 본 발명은 판토텐산 칼슘, 또는 판토텐산 칼슘 및 디멘하이드리네이트를 유효 성분으로 함유하는 근육 질환의 예방 및 치료용 약학조성물에 관한 것으로, 본 발명의 판토텐산 칼슘은 MHC, 미오게닌 4-EBP 및 p70S6K의 발현을 증가시켜 근육 분화 및 근육 생성을 촉진시킴으로써 근위축성 측색 경화증 환자의 생존 기간을 연장시키고, 뒤센 근이영양증 마우스의 MSC의 생장을 촉진시키는 효과가 있으며, 이와 같은 효과는 디멘하이드리네이트와의 병용 처리의 병용 처리에 의해 시너지적으로 증가하므로, 이들을 근육 질환의 예방 또는 치료 용도로 유용하게 활용할 수 있다.