VIRAL PARTICLES FOR USE IN TREATING TAUOPATHIES SUCH AS ALZHEIMER'S DISEASES BY GENE THERAPY

• Main Authors: SUCUNZA GUIBERT, Diego, LANCIEGO PÉREZ, José Luis, LINDEN, Ralph Michael, GONZÁLEZ-ASEGUINOLAZA, Gloria
• Format: Patent
• Language: English; French
• Published: 10.02.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present disclosure relates to viral particles for use in treating tauopathies, particularly Alzheimer's disease, by gene therapy. More specifically, the present invention relates to a viral particle for use in treating tauopathies by gene therapy in a subject in need thereof, said viral particle comprising a nucleic acid construct including a transgene encoding a glucocerebro sidase. La présente invention concerne des particules virales à utiliser dans le traitement de tauopathies, en particulier la maladie d'Alzheimer, par thérapie génique. Plus spécifiquement, la présente invention concerne une particule virale à utiliser dans le traitement de tauopathies par thérapie génique chez un sujet en ayant besoin, ladite particule virale comprenant une construction d'acide nucléique comprenant un transgène codant pour une glucocérébrosidase.