ENGINEERED MULTI-SPECIFIC ANTIBODIES AND RELATED METHODS OF USE AND MANUFACTURE

Provided herein are multispecific antigen binding proteins (ABPs). Also provided herein are multispecific ABPs that are engineered to form diabodies or stay in extended (dual scFv) conformation and methods for purifying ABPs based on avidity. L'invention concerne des protéines multi-spécifiques...

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Bibliographic Details
Main Authors RAINEY, Godfrey Jonah Anderson, HWANG, Shan Liu, RONDON, Isaac J, JOOSS, Karin, PRAKASH, Gayatri
Format Patent
LanguageEnglish
French
Published 03.02.2022
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
TESTING
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Summary:Provided herein are multispecific antigen binding proteins (ABPs). Also provided herein are multispecific ABPs that are engineered to form diabodies or stay in extended (dual scFv) conformation and methods for purifying ABPs based on avidity. L'invention concerne des protéines multi-spécifiques de liaison à l'antigène (ABP). L'invention concerne également des ABP multi-spécifiques qui sont modifiées pour former des diabodies ou rester dans une conformation étendue (scFv double) et des procédés de purification des ABP faisant appel à l'avidité.
Bibliography:Application Number: WO2021US43796