COMPOUND FOR INHIBITING OR DISINTEGRATING ANDROGEN RECEPTOR, AND PHARMACEUTICAL USE THEREOF

• Main Authors: WOO, Yaejin, AHN, Jungmin, KIM, Hyun Jin, PARK, Byoung Chul, RYU, Je Ho, KIM, Jeong Hoon, LEE, Song Hee, PARK, Sung Goo, CHO, Sung Yun, KIM, Hanwool, KIM, Pilho, CHOI, Yuri, HA, Jae Du, PARK, Ji Youn, HWANG, Jong Yeon, KIM, Sunhong, LEE, Chong Ock, BAE, Onnuri
• Format: Patent
• Language: English; French; Korean
• Published: 03.02.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present disclosure provides a compound of a chemical structure having the ability of inhibiting or disintegrating an androgen receptor (AR), or a pharmaceutically acceptable salt of the compound. The present disclosure also provides a composition comprising such a compound or a pharmaceutically acceptable salt thereof. The present disclosure provides a pharmaceutical use of a compound according to the present disclosure, a salt thereof, and a composition comprising same for the treatment or prevention of AR-related diseases. The present disclosure also provides a method for treating or preventing AR-related diseases, comprising administering to a subject in need of treatment an effective amount of a compound according to the present disclosure, a salt thereof, or a composition comprising same. La présente divulgation concerne un composé d'une structure chimique ayant la capacité d'inhiber ou de désintégrer un récepteur des androgènes (AR), ou un sel pharmaceutiquement acceptable du composé. La présente divulgation concerne également une composition comprenant un tel composé ou un sel pharmaceutiquement acceptable de celui-ci. La présente divulgation concerne une utilisation pharmaceutique d'un composé selon la présente divulgation, un sel de celui-ci, et une composition le comprenant pour le traitement ou la prévention de maladies associées au AR. La présente divulgation concerne en outre une méthode de traitement ou de prévention de maladies associées au AR, comprenant l'administration à un sujet ayant besoin d'un traitement d'une quantité efficace d'un composé selon la présente divulgation, d'un sel de celui-ci, ou d'une composition le comprenant. 본 개시는 안드로겐 수용체(androgen receptor; AR)를 저해 또는 분해하는 활성을 갖는 특정 화학구조의 화합물 또는 이의 약학적으로 허용 가능한 염을 제공한다. 본 개시는 또한 이러한 화합물 또는 이의 약학적으로 허용 가능한 염을 포함하는 조성물을 제공한다. 본 개시는 본 개시에 따른 화합물, 이의 염 및 이들을 포함하는 조성물의 AR 관련 질환의 치료 또는 예방용 의약 용도를 제공한다. 본 개시는 또한 본 개시에 따른 화합물, 이의 염 또는 이들을 포함하는 조성물의 유효한 양을 치료가 필요한 개체에게 투여하는 것을 포함하는 AR 관련 질환의 치료 또는 예방 방법을 제공한다.