COMPOUND USEFUL AS CDK7 KINASE INHIBITOR AND USE THEREOF

• Main Authors: NIU, Chengshan, LIANG, Apeng, WU, Yusheng, DONG, Shengli, LI, Jun, LI, Meihua
• Format: Patent
• Language: Chinese; English; French
• Published: 27.01.2022
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to a compound useful as a CDK7 kinase inhibitor and use thereof. Specifically, the compound of the present invention has a structure shown in formula I, wherein the definition of each group and substituent is as described in the description. The compound of the present invention can be used as an inhibitor of cyclin-dependent kinase 7 (CDK7) for the treatment or prevention of proliferative diseases (such as cancers), and in particular for the regulation and treatment of related diseases caused by abnormal activity of cyclin-dependent kinase 7 (CDK7). La présente invention concerne un composé utile en tant qu'inhibiteur de kinase CDK7 et son utilisation. En particulier, le composé selon la présente invention a la structure représentée par la formule I, dans laquelle la définition de chaque groupe et substituant est telle que décrite dans la description. Le composé selon la présente invention peut être utilisé comme inhibiteur de la kinase dépendante de la cycline 7 (CDK7) pour le