THREE-DIMENSIONAL BIOMIMETIC CHIP FOR SIMULATING ENDOMETRIUM, AND ENDOMETRIUM SIMULATING METHOD USING SAME

• Main Authors: KANG, Youn Jung, HONG, Seon Hwa, YOON, Min Ji, CHA, Hwi Jae, AHN, Jung Ho
• Format: Patent
• Language: English; French; Korean
• Published: 30.12.2021
• Subjects: APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The present invention relates to a biomimetic chip for simulating the endometrium in three dimensions, and an endometrium simulating method using same. The three-dimensional biomimetic chip for simulating the endometrium according to an embodiment of the present invention comprises: a plate; a plurality of chambers; and a plurality of posts disposed between the plurality of chambers, wherein the plurality of chambers include channels which are provided therein and in which different cells are cultured, and the plurality of chambers are disposed on the plate in parallel with each other in one direction and disposed adjacent to each other such that at least some sections thereof are in communication with each other. Puce biomimétique tridimensionnelle pour simuler l'endomètre, et procédé de simulation de l'endomètre l'utilisant. La puce biomimétique tridimensionnelle pour simuler l'endomètre selon un mode de réalisation de la présente invention comprend les éléments suivants : une plaque ; une pluralité de chambres ; et une pluralité de montants disposés entre la pluralité de chambres, la pluralité de chambres comprenant des canaux prévus à l'intérieur et dans lesquels différentes cellules sont cultivées, et la pluralité de chambres étant disposée sur la plaque parallèlement les unes aux autres dans une direction et disposée de manière adjacente les unes aux autres de sorte qu'au moins certaines de leurs sections sont en communication les unes avec les autres. 본 발명은 자궁 내막을 3차원으로 모사하는 생체 모사 칩 및 이를 이용한 자궁 내막 모사 방법에 관한 것이다. 본 발명의 일 실시예에 따른 생체 모사 칩은 플레이트와, 복수 개의 챔버와, 상기 복수 개의 챔버 사이에 배치되는 복수 개의 포스트를 포함하는 자궁 내막을 모사하는 3차원 생체 모사 칩으로서, 상기 복수 개의 챔버는 내부에 서로 다른 세포가 배양되는 채널을 구비하며, 상기 플레이트 상에 일 방향으로 나란히 배치되고, 적어도 일부 구간이 연통하도록 서로 인접하여 배치된다.