ISOFORM-SPECIFIC ALDEHYDE DEHYDROGENASE INHIBITORS

• Main Authors: CHEN, James Kenneth, MARSHALL, Cody R, ONDRUS, Alison E, HOM, Marisa E, FENG, Zhiping, KLIINE, Toni
• Format: Patent
• Language: English; French
• Published: 23.12.2021
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Compounds and methods are provided for inhibiting an aldehyde dehydrogenase (ALDH). Methods of treating cancer are also provided. The ALDH-inhibitor can be a compound that is based on a cyclic guanidine, or an imidazolium core. In certain embodiments, the ALDH-inhibitor compound is a substituted cyc...