ANTI-VSIG4 COMPOSITIONS AND METHODS FOR MODULATING MYELOID CELL INFLAMMATORY PHENOTYPES AND USES THEREOF

• Main Authors: CULYBA, Elizabeth, NGUYEN, Phuong, SAZINSKY, Stephen, NOVOBRANTSEVA, Tatiana, RAZLOG, Maja, FELDMAN, Igor
• Format: Patent
• Language: English; French
• Published: 02.12.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present invention is based, in part, on the discovery of anti-VSIG4 composition (e.g., monoclonal antibodies and antigen-binding fragments thereof), that regulate myeloid cell inflammatory phenotypes, such as suppressive myeloid cells, monocytes, macrophages, neutrophils, and/or dendritic cells, including polarization, activation, and/or function, and methods of using such anti-VSIG4 compositions for therapeutic, diagnostic, prognostic, and screening purposes. La présente invention est basée, en partie, sur la découverte d'une composition anti-VSIG4 (par exemple, des anticorps monoclonaux et leurs fragments de liaison à l'antigène), qui régulent les phénotypes inflammatoires des cellules myéloïdes, tels que les cellules myéloïdes suppressives, les monocytes, les macrophages, les neutrophiles et/ou les cellules dendritiques, comprenant la polarisation, l'activation et/ou la fonction, et des procédés d'utilisation de ces compositions anti-VSIG4 à des fins thérapeutiques, diagnostiques, pronostiques et de criblage.