ANTI-VSIG4 COMPOSITIONS AND METHODS FOR MODULATING MYELOID CELL INFLAMMATORY PHENOTYPES AND USES THEREOF
The present invention is based, in part, on the discovery of anti-VSIG4 composition (e.g., monoclonal antibodies and antigen-binding fragments thereof), that regulate myeloid cell inflammatory phenotypes, such as suppressive myeloid cells, monocytes, macrophages, neutrophils, and/or dendritic cells,...
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Main Authors | , , , , , |
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Format | Patent |
Language | English French |
Published |
02.12.2021
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Subjects | |
Online Access | Get full text |
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Summary: | The present invention is based, in part, on the discovery of anti-VSIG4 composition (e.g., monoclonal antibodies and antigen-binding fragments thereof), that regulate myeloid cell inflammatory phenotypes, such as suppressive myeloid cells, monocytes, macrophages, neutrophils, and/or dendritic cells, including polarization, activation, and/or function, and methods of using such anti-VSIG4 compositions for therapeutic, diagnostic, prognostic, and screening purposes.
La présente invention est basée, en partie, sur la découverte d'une composition anti-VSIG4 (par exemple, des anticorps monoclonaux et leurs fragments de liaison à l'antigène), qui régulent les phénotypes inflammatoires des cellules myéloïdes, tels que les cellules myéloïdes suppressives, les monocytes, les macrophages, les neutrophiles et/ou les cellules dendritiques, comprenant la polarisation, l'activation et/ou la fonction, et des procédés d'utilisation de ces compositions anti-VSIG4 à des fins thérapeutiques, diagnostiques, pronostiques et de criblage. |
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Bibliography: | Application Number: WO2021US34784 |