METHODS FOR THE PREPARATION OF SPHINGOSINE 1-PHOSPHATE RECEPTOR MODULATORS AND SOLID FORMS THEREOF
The present invention relates to process for preparation of 1-(4-{1-[(E)-4-cyclohexyl-3-trifluoromethyl-benzyloxy imino]ethyl}-2-ethyl-benzyl)-azetidine-3-carboxylic acid, intermediates, salts and solid forms thereof to pharmaceutical compositions comprising the salts and solid forms and to use of s...
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Main Authors | , , , , , , , |
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Format | Patent |
Language | English French |
Published |
06.01.2022
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Subjects | |
Online Access | Get full text |
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Summary: | The present invention relates to process for preparation of 1-(4-{1-[(E)-4-cyclohexyl-3-trifluoromethyl-benzyloxy imino]ethyl}-2-ethyl-benzyl)-azetidine-3-carboxylic acid, intermediates, salts and solid forms thereof to pharmaceutical compositions comprising the salts and solid forms and to use of said compositions for the treatment of multiple sclerosis, particularly secondary progressive multiple sclerosis.
La présente invention concerne un procédé de préparation de 1-(4-{1-[(E)-4-cyclohexyl-3-trifluorométhyl-benzyloxy imino]éthyl}-2-éthyl-benzyle)-azétidine-3-carboxylique, des intermédiaires, des sels et des formes solides de ceux-ci, des compositions pharmaceutiques comprenant les sels et les formes solides et l'utilisation desdites compositions pour le traitement de la sclérose en plaques, en particulier la sclérose en plaques progressive secondaire. |
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Bibliography: | Application Number: WO2021IN50515 |