FUSED IMIDAZOLE DERIVATIVES AS AHR ANTAGONISTS

The present disclosure relates to compounds of formulae (I) - (VI) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the same, methods of preparing the same, intermediate compounds useful for preparing the same, and methods for treating or prophylaxis of diseases,...

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Main Authors BARTOLOZZI, Alessandra, LY, Vu Linh, BUCKBINDER, Leonard, PROUDFOOT, John Robert, MANCUSO, John, BOS, Maxence, BLOIS, Anna, LANTER, Bernard, TAYLOR, Steven John, BRIGGS, Timothy
Format Patent
LanguageEnglish
French
Published 25.11.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present disclosure relates to compounds of formulae (I) - (VI) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the same, methods of preparing the same, intermediate compounds useful for preparing the same, and methods for treating or prophylaxis of diseases, in particular cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling. La présente invention concerne des composés de formules (I)-(VI) et des sels pharmaceutiquement acceptables de ceux-ci, des compositions pharmaceutiques les comprenant, des procédés de préparation de ceux-ci, des composés intermédiaires utiles pour la préparation de ceux-ci, et des méthodes de traitement ou de prophylaxie de maladies, en particulier du cancer ou d'états avec des réponses immunitaires dérégulées ou d'autres troubles associés à une signalisation aberrante de l'AHR.
Bibliography:Application Number: WO2021US33078